Joseph Clemence Rwegasira (March 21, 1935 – March 4, 2016) was a Tanzanian politician and diplomat. Rwegasira, a former member of the National Assembly for Nkenge Constituency, served as Minister of Foreign Affairs from 1993 to 1995. He also held the government portfolios of Minister for Trade and Industry and Minister for Labour and Youth Development at various times during his political career. He had also served as a Regional Commissioner for Dar es Salaam at one time.
Rwegasira had served as Tanzania's Ambassador to neighboring Zambia from 1979 - 1982